AIDD研究员 — 恒瑞-全球精英计划 Job at Hengrui Pharma, Princeton, NJ

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  • Hengrui Pharma
  • Princeton, NJ

Job Description

Location: Shanghai

Track 1: Small Molecule CADD

Lead structure-based drug design: Perform molecular docking, virtual screening, and binding mode analysis using Schrödinger/MOE.

Optimize lead compound

Develop ADMET prediction models

Track 2: AI Drug Discovery (AIDD)

Develop AI molecular generation tools:

Generate novel compound structures with Diffusion/RL/GAN models

Predict molecular activity and ADMET using Graph Neural Networks/Transformers

Build data-driven pipelines: Train customized AI models by integrating ChEMBL/patent data

Track 3: Macromolecular & Target Discovery

Macromolecular structure modeling:

Predict protein/antibody structures with AlphaFold3/Rosetta

Design PPI inhibitors/degraders (PROTACs)

Omics data mining: Discover novel targets and biomarkers through multi-omics integration analysis

Basic Requirements

Education: MS/PhD in Computational Chemistry, Bioinformatics, Computer Science, AI, or related fields

Collaboration Skills: Ability to clearly interpret computational results for chemistry/biology teams and guide experimental design

Preferred Qualifications

Tool Development: Proficiency in Python for scripting automation (e.g., MD analysis, AI model deployment)

Industry Experience: Demonstrated tangible outcomes in drug discovery projects (e.g., advancing compounds to Hit-to-Lead stage)

Technical Versatility: Understanding of cross-domain integration (e.g., utilizing AlphaFold3 outputs for molecular docking)

Job Tags

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