Job Description

Position Summary:

TRexBio is seeking a talented and motivated contractor computational biologist to be part of a dynamic and innovative computational biology team. Our group is elucidating the biology of tissue-resident immune cells to develop next generation immunotherapies for inflammatory and autoimmune diseases. The team’s core competencies are bioinformatics, data science, software engineering, biology, and scientific communication. The Computational Biology group sits upon a wealth of internal and public data, including genetics, single-cell omics, perturbational RNA-seq and mined literature, and uses these data to launch and support therapeutic programs. There is ample opportunity for professional growth and exposure to the diverse aspects of drug discovery in the biotech space. Come join our team!

Key Responsibilities include but are not limited to:

• Implement and develop bioinformatics pipelines to facilitate robust data analysis
• Perform data analysis, data interpretation and strategic planning of next steps
• Coordination with other scientists in planning and executing experiments
• Organization of records and data, interpretation, and presentation of results
• Support the lifecycle of pre-clinical therapeutic development
• Provide analysis for target discovery
• Support Indication selection and MOA interrogation
• Perform safety risk prediction analysis
• Biomarker discovery
• Consult on design of experiments in clinical trials

Required Qualifications:

• Advanced Python and R
• AWS Cloud computing know-how
• Bioinformatics pipeline expertise
• scRNA-seq experience
• Docker experience
• Machine Learning experience
• Strong experience using and maintaining relational databases
• Top-notch cross-disciplinary communication and presentation skills
• Exposure to immunology
• Diligent, highly motivated self-starter with a strong growth mindset and a positive “can-do” attitude towards assigned tasks
• Good planning and organizational skills to meet deadlines
• Proven ability to collaborate in a team-oriented environment, and excellent written and interpersonal communication skills are a must

Preferred Qualifications:

• Experience with single-cell VDJ, ATAC, and CITEseq
• Advanced degree in a relevant field, e.g. Immunology or Computational Biology
• Biotech industry experience, especially in preclinical drug discovery
• Web application development (JS, Flask, RShiny & Django)
• Immunology expertise
• NGS experimental design
• Computational structural biology and machine learning
• LLMs, RAG/GraphRAG, and knowledge graphs
• Docker and GitHub

Opportunities

• Support the development of life changing therapeutics from discovery through the clinic
• Autonomy
• Collaborate with world class scientists
• Journal publications

TRexBio is a discovery stage biotechnology company leveraging cutting edge computational biology tools, a focus on human tissue, and expertise in immunobiology to develop revolutionary therapeutics for inflammatory diseases. Our powerful ‘deep biology’ discovery engine maps human tissue Treg behavior to disease processes, allowing us to identify and characterize novel targets for therapeutic intervention. Leveraging this platform, we are building a broad portfolio of novel therapies that modulate the immune system to restore human tissue immune homeostasis.

Our Culture:

At TRexBio, you will have the opportunity to work with world class researchers who strive to make the world a better place. In addition to our team-centric culture, we believe that your individual creativity will help us to be our best. Our staff happy hours, organized by our Culture Club, bring us all together in creative and social activities. Our colleagues admire and respect one another. We celebrate our wins, update company news and acknowledge each other’s achievement weekly and monthly at all company meetings that celebrate our work and our people.

TRexBio is proud to be an AA/EEO employer and all qualified candidates will receive consideration without regard to characteristics protected by applicable local, state, or federal law, such as race, color, sex, age, religion, national origin, physical or mental disability, pregnancy, marital status, veteran or military status, genetic information, or sexual orientation.

Job Tags

Similar Jobs